Streblus asper Lour. exerts MAPK and SKN-1 mediated anti-aging, anti-photoaging activities and imparts neuroprotection by ameliorating Aβ in Caenorhabditis elegans

BACKGROUND: Streblus asper Lour., has been reported to have anti-aging and neuroprotective efficacies in vitro. OBJECTIVE: To analyze the anti-aging, anti-photoaging of S. Caenorhabditis elegans. METHODS: C. elegans (wild type gene specific mutants) were treated with extract analyzed for lifespan other health benefits through physiological assays, fluorescence microscopy, qPCR Western blot. RESULTS: The plant was found increase lifespan, reduce accumulation lipofuscin modulate expression candidate genes. It could extend both daf-16 daf-2 mutants whereas pmk-1 mutant showed no effect. activation skn-1 observed skn-1::GFP transgenic strain expression. Further, can UV-A exposed nematodes along reducing ROS levels. Additionally, also extends reduces paralysis Aβ strain, apart from CONCLUSIONS: able healthspan which independent DAF-16 pathway but dependent on SKN-1 MAPK play a vital role eliciting effects, as impart oxidative stress resistance neuroprotection.